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Changes in the biochemical parameters of blood in cows in the latent course of leptospirosis have been studied by the results of the reaction of microagglutination (RMA). The dynamics of biochemical blood parameters is manifested by hyperproteinemia, dysproteinemia, hemolytic anemia, hyperbilirubinemia, intra- and extrahepatic cholestasis, hyperfermentemia, mineral metabolism disorders, in particular hypocalcemia, hypophosphatemia, indicating the development of hepatopathy which should be classified as hepatocholangitis. It was determined that the pathological process is manifested in all animals for the titer of antibodies to one or another Leptospira serovar. Significant changes from the side of the hepatobiliary system in infested cows for the antibody titer kabura equaling 1:100, polonica 1:200, ballum 1:100, szvajzak 1:100–1:200, bratislava 1:800 and in animals for the titers kabura of 1:100–1:200; polonium 1:100; szvajzak 1:100–1:200; ballum 1:100; bratislava 1:100–1:200. At leptospirosis caused by bratislava and ballum serovars, a disorder of the functional state of the hepatobiliary system, characterized by an increase in the level of total protein, bilirubin, AST, GGTP and ALP activity was diagnosed as the urea, calcium and phosphorus levels in blood decreased. In the case of the latent course of the disease caused by kabura, polonica, szvajzak, ballumand bratislava serovars, a probably higher concentration of bilirubin, activity of aminotransferases (AST and ALAT), GGTP and ALP was determined in comparison to clinically healthy animals. In cows, in the presence of antibody titers kabura 1:100, polonica 1:200, ballum 1:100, szvajzak 1:100–1:200; bratislava 1:800, in 22.2% of cases, we recorded increase in the total protein against the background of dysproteinemia in 50.0–88.9% of animals, and increase in bilirubin in 78.6%, and increase in the activity of blood serum enzymes (AST, ALAT, GGTP, ALP), and also hypocalcemia and hypophosphatemia in 33.3–100.0%. The conducted studies indicate that in latent leptospirosis in cows, in addition to etiotropic therapy, one should include in the protocol the pharmacological correction preparations, which would contribute to the restoration of the functional state of the hepatobiliary system.

Biochemical parameters of blood in cows in latent course of leptospirosis