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The significant spread of antibiotic-resistant microorganisms which are part of microbial associations of the oral cavity is considered one of the main causes for the complications and relapses of inflammatory diseases of the periodontium. This problem underlines the importance of constant monitoring of the circulation of polyantibiotic-resistant isolates, and development of new approaches and means of correction for the microbiocoenosis of the oral cavity affected by inflammatory processes. The paper is dedicated to research of antimicrobial properties of essential oil compositions against opportunistic pathogenic microorganisms, agents of inflammatory diseases of the periodontium. Out of the microorganisms isolated from the nidus of inflammation, the extra antibiotic-resistant ones were chosen. For the purpose of antibiotic susceptibility and antimicrobial activity testing, the disc diffusion method was used. The following compositions were manufactured from essential oils: Hyssopus officinalis L. + Rossmarinus officinalis L.; Menta piperita L. + H. officinalis; R. officinalis + Coriandrum sativum L.; R. officinalis + M. piperita + H. officinalis. The compositions H. officinalis + R. officinalis; M. piperita + H. officinalis were shown to have the highest level of antibacterial activity against clinical and typical isolates. Combinations of essential oils demonstrated a broader spectrum of activity against microorganisms than their components taken separately. Certain essential oils and the compositions H. officinalis + R. officinalis; M. piperita + H. officinalis were ascertained to have a high anti-mycotic activity against Candida genus microscopic fungi. This fact proves the advantage of application of combinations of essential oils compared to the use of their separate components. However, not all variants reviewed showed additive antimicrobial effect of the use of combinations of essential oils. The compositions that showed high antibacterial properties against the reviewed isolates may be used for oral hygiene products.

regulatory mechanisms in biosystems

Compositions of essential oils with antimicrobial properties against isolates from oral cavities of patients with inflammatory diseases of the periodontium