Open AccessGenome-Wide Association and Exome Sequencing Study of Language Disorder in an Isolated Population
Author(s) -
Sergey A. Kornilov,
Natalia Rakhlin,
Roman Koposov,
Maria Lee,
Carolyn M. Yrigollen,
Ahmet Okay Çağlayan,
James S. Magnuson,
Shrikant Mane,
Joseph T. Chang,
Elena L. Grigorenko
Publication year - 2016
Publication title -
pediatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.611
H-Index - 345
eISSN - 1098-4275
pISSN - 0031-4005
DOI - 10.1542/peds.2015-2469
Subject(s) - exome sequencing , exome , genetics , genome wide association study , genetic association , candidate gene , population , gene , medicine , phenotype , biology , computational biology , single nucleotide polymorphism , genotype , environmental health
Developmental language disorder (DLD) is a highly prevalent neurodevelopmental disorder associated with negative outcomes in different domains; the etiology of DLD is unknown. To investigate the genetic underpinnings of DLD, we performed genome-wide association and whole exome sequencing studies in a geographically isolated population with a substantially elevated prevalence of the disorder (ie, the AZ sample).
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