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espanolIntroduccion: el proposito de este estudio experimental es investigar la variabilidad en la reabsorcion osea de aloinjertos impregnados con alendronato respecto a aloinjertos sin impregnacion con alendronato.Materiales y Metodos: se utilizaron 18 conejos neozelandeses, divididos en dos grupos de 9 animales cada uno. Se trabajo sobre el femur derecho, se realizo una ventana osea y se coloco aloinjerto con alendronato local en el grupo I y aloinjerto sin alendronato en el grupo II. Todos fueron sacrificados a las 10 semanas del procedimiento inicial, y se valoro el femur operado con anatomia patologica, radiografias de frente y de perfil, y tomografia axial computarizada. Se evaluaron la osteointegracion, la vascularizacion y la calidad osea. Resultados: el estudio histologico demostro mayor osteointegracion en el grupo I que en el grupo II (p = 0,003), y fenomenos bien definidos de “acoplamiento” entre el tejido oseo receptor e injertado, leve actividad osteoclastica. En el grupo II, se observo menor acoplamiento oseo (osteointegracion). La evaluacion de la reabsorcion osea con radiografia y tomografia computarizada no revelo una diferencia estadisticamente significativa entre ambos grupos. En el grupo I, se observo mayor osteointegracion del aloinjerto (p = 0,577; no significativo). Conclusion: los resultados obtenidos en este trabajo experimental muestran que el alendronato local asociado a aloinjertos ayuda a mejorar la osteointegracion de los aloinjertos, que es un metodo seguro, y que no se asocia a riesgos locales o sistemicos en conejos, aun en dosis elevadas. EnglishBackground: the use of allografts in bone reconstruction may be associated with an increased absorption of the latter, which may cause loss of stability and failure of reconstructions. The purpose of this experimental study was to investigate the variability in bone resorption in alendronate-impregnated allografts versus non-impregnated allografts.Methods: eighteen New Zealand rabbits were divided into two groups of nine animals each. We worked on the right femur; a bone window was performed and allografts were placed (with alendronate in group I and without alendronate in group II). All rabbits were sacrificed at 10 weeks after the initial procedure. Femur was evaluated with pathology, frontal and lateral radiographs and computed tomography. Osteointegration, vascularization and bone quality were evaluated.Results: no deaths or infections were reported, with 18 rabbits up to final analysis. Histology showed better osteointegration in group I than group II (p = 0.003), with well-defined attachment between receptor bone tissue and low osteoclastic activity. In group II, we observed less osteointegration. Assessment of bone resorption with radiographs and computed tomography showed no statistically significant difference between both groups. Group I showed more osteointegration of the allograft (p = 0.577; not significant). Conclusions: results of this experimental study show that allografts impregnated with alendronate help to improve the osteointegration. Also, it is a safe way and it is not associated with local or systemic risks in rabbits, even with high doses of alendronate.

revista de la asociación argentina de ortopedia y traumatología

Integración de los aloinjertos óseos impregnados con alendronato: Estudio experimental. [Alendronate-impregnated bone allograft integration: Experimental study]