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Synthesis of N-Octylcinnamamide compound derived from methyl trans-cinnamate using abase catalyst has been done. First, The compound of methyl trans-cinnamate was converted into cinnamic acid by hydrolysis reaction with an alkaline condition. Furthermore cinnamic acid was amidated by using octylamine and 1.3 dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP) as a catalyst. The results of this study were obtained synthesis of cinnamic and synthesis of NOctylcinnamamide are good enough. Identification of this product was using by 1 H-NMR, 13 C-NMR and LC-MS. Cytotoxic test of N-Octylcinnamamide against P388 leukemia cells was obtained IC50= 6.71μg/mL.

Synthesis N-Octylcinnamamide and Cytotoxicity Activity against P388 Leukemia Cancer Cells