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Streptomyces globisporus 1912 and their derivatives 1912-4Crt and 1912-2 are the producers of the landomycin E, carotenoids and regulatory diketopiperazine, respectively. The genome DNA of two mutant strains, 1912-2, the more effective producer of the landomycin E and regulator, and 1912-4Crt, the producer of beta-carotene and lycopene, was sequenced by Illumina. Comparative analysis of the DNA sequences of two neighboring contigs of 1912-2 and one contig of 1912-4Crt using GenBank data allowed localization of 36 landomycin E biosynthetic genes lnd of S. globisporus 1912 in one cluster. Twenty of these lnd genes have been sequenced for the fi rst time. The new regulatory responce gene lndRR and the sensor kinase gene lndY1 were proposed as the members of the putative two-component system. A high identity (94-95%) was found for the lnd genes of the 1912 strain and those of the metagenomic clone AZ97, and the lower similarity (80-85%) of lnd and lan genes of S. cyanogenus S136 encoding landomycin A biosynthesis. Two direct repeats of 21 bp were shown in the crtY gene coding lycopene cyclase. A deletion in the lndRR gene renders the 1912-4Crt strain defi cient in landomycin E production. K e y w o r d s: Streptomyces globisporus, landomycin E, biosynthetic gene cluster, sequences.

Complete Sequence of Landomycin E Biosynthetic Gene Cluster from Streptomyces globisporus 1912