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We studied the changes in the cellular composition of the duodenal’s crypts induced by chronic action of Epichlorohydrin (ECH) and the efficiency of the treatment by Echinacea purpurea (EP) extract and thiotriazoline for possible correction of these changes. On the 15th, 30th and 60th days, rats subjected to ECH, EP and thiotriazoline were removed from the experiment. According to the standard histological technique, sections of duodenum were processed, stained with hematoxylin-eosin, acid fuchsine and picric acid. Chronic exposure to ECH on duodenum led to statistically significant changes in the cellular composition of the crypts, which persisted after the cessation of the action of the chemical. On the 15th day, there was a decrease in the total number of cells in one crypt of the duodenal mucous membrane (MM), the number of columnar epithelial cells, argyrophilic endocrinocytes and Paneth cells in one crypt of the duodenal MM compared with the corresponding indicators in rats of the control group. Administration of EP extract and thiotriazoline on the background of chronic action of ECH prevented the development of negative changes in crypt composition of the duodenal MM.

CHANGES IN THE CELLULAR COMPOSITION OF THE CRYPTS OF THE DUODENUM IN RATS UNDER THE INFLUENCE OF THE CHRONIC ACTION OF EPICHLOROHYDRIN