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The effect of pharmacological blockade of ASIC1a channels on emotionally conditioned learning in rats with lithiumpilocarpine model of temporal lobe epilepsy was studied. The development of status epilepticus is known to impair both contextual and stimulated emotional learning. In our experiments, the painful effect was directly accompanied by freezing in animals of all groups, however, under conditions of induced epilepsy, its duration was shorter, and blocking ASIC1a channels neutralized this difference. The induction of epilepsy disrupted both contextual and stimulated emotional learning. Suppression of ASIC1a channels partially restored this process in animals with induced epilepsy. This means that pharmacological blocking of ASIC1a channels can have a positive therapeutic effect in correcting the emotional disorders associated with temporal lobe epilepsy.

PHARMACOLOGICAL BLOCKADE OF ACID SENSING ION CHANNELS NORMALIZES EMOTIONALLY CONDITIONED LEARNING DISTURBED DUE TO EPILEPTIC STATUS