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The experimental studies on 80 white rats, which were divided into 4 groups of 20 animals each, were conducted to estimate the influence of anthropogenic load in conditions of iodine, fluorine deficit on the state of periodontal tissues in rats. Group 1 – intact animals; group 2 – rats with peroxidation model of gingivitis; group 3 – animals exposed to heavy metals, by adding to the water of inorganic toxicants of cadmium and lead on the background of experimental model of gingivitis; group 4 – rats with experimental gingivitis on the background of exposure to heavy metals, iodine deficit, which was caused by the addition of water mercazole and fluoride deficit, which was modeled by keeping animals on a low calorie diet. The analysis of immunological status of experimental animals was estimated for the content of cytokines in blood serum. The content of cytokines (IL-1β, IL-6, TNF-α, IL-4) in blood serum of rats was determined by ELISA using commercial sets „Vector Best” and transforming growth factor – β1 (TGF-β1) by using the system Quanticine. As a result of researches it is established that minimal immunological changes according to the results of studies were observed in group 2 of animals with modeled gingivitis and a maximal in group 4, where experimental gingivitis was modeled with a combined effect of anthropogenic factors, which in turn emphasizes the importance of xenobiotics in combination with deficit of essential microelements and intensification of the inflammatory process in animals.

Evaluation of influence of heavy metals, iodine and fluoride deficiency on the indices of the immune system of rats with gingivitis