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Amniotic cavity contains amniotic fluid which plays an important role to guarantee fetal movements (essential for the skeletal development), fetal chest and lungs development and to protect against umbilical cord compression, fetal trauma and infections. Premature rupture of membranes (PROM) is the rupture of the chorioamniotic membrane before the onset of labor (1). It complicates approximately 2% of pregnancies and it determines a significantly increasing of neonatal morbidity and mortality because in the 40% of cases it causes preterm delivery. The management of PPROM requires a careful evaluation of benefits of prolongation of the pregnancy and risks of intra-amniotic infection, in order to minimize maternal and fetal complications. There are a few possibilities: expectant management, amnioinfusion, sealing techniques; termination of pregnancy is proposed to women in case of high risks of maternal sepsis and very poor fetal outcome. In this paper we report the case of a woman with iatrogenic PPROM post amniocentesis at 17th week of gestation treated by amniopatch. At the end of the procedure maternal and fetal conditions were good and amniotic fluid was restored. The procedure was repeated twice and the patient gave birth at 32 weeks. Currently, due to the lack of evidence in the scientific literature, there is no evidence of the superiority of a therapeutic option over the others. The management of PPROM should be based on the clinical evaluation of the specific case. We suggest considering transabdominal sealing technique when the expectant management failed.

An iatrogenic preterm premature rupture of the membranes: a case report treated by amniopatch