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Background Clopidogrel has been used as a gold standard alone or in association with aspirin to prevent vascular complications in atherothrombotic patients undergoing PCI and as a long term prevention of cardiovascular events The drug is subject to efflux via P glycoprotein encoded by the ABCB gen also known as MDR The ABCB C T polymorphism may be associated with altered drug metabolism efficacy and clinical outcome The aim of this study was to evaluate the influence of ABCB C T genotype on clinical cardiovascular outcomes in coronary artery disease patients on clopidogrel treatment Methods The study included a total of subjects of which healthy volunteers and patients diagnosed with coronary artery disease on treatment with clopidogrel from the Special Hospital for Surgical Diseases quot Filip II quot The genotyping of both the control group and the patient group was performed with Real Time PCR based on the allelic discri shy mi shy na shy tion method Statistical analysis was performed using SPSS software The genotype distri shy butions were assessed for the Hardy Weinberg equilibrium HWE with chi test Results The C T allele and genotype frequency distribution testing in the patient group showed that the polymorphism is not associated with a risk of atherosclerotic cardiovascular disease ACD in the Macedonian population p gt A higher C risk allele frequency was found in the subgroup of patients with negative outcome after treatment compared to the subgroup of patients with positive outcome vs OR T reg C p The same trend was observed when following the C T allele and genotype distribution in the subgroup of patients with normal CYP C genetic status CYP C vs OR T reg C p Conclusion The results indicate that the ABCB C T polymorphism is an independent and complementary genetic factor that affects the outcome of clopidogrel treatment but requires further research and abigger study population

Influence of ABCB1 C3435T Genotype on Clinical Cardiovascular Outcomes in Coronary Artery Disease Patients on Clopidogrel Treatment