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Ischemic preconditioning is a technique where prior application of repeated short cycles of ischemia and reperfusion would be able to attenuate the severity of the subsequent ischemic reperfusion injury (IRI). Remote ischemic preconditioning (RIPC) describes the ability of the technique to function through distance. For example, the application of short, repetitive ischemia-reperfusion cycles of the limb would protect distant organs like heart, kidney, brain, and liver during subsequent IRI. Both phenomena indicate the involvement of local, paracrine, as well as remote circulating mediators [1].

NO2- Mediates the Heart Protection of Remote Ischemic Preconditioning