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Nowadays, Chinese traditional medicines are being increasingly concerned in the treatment of ischemic brain vascular diseases. The Tibetan herb of Potentilla anserina, belonging to the genus Potentilla, is widely distributed in the western areas of China. For thousands ofyears, this Tibetan traditional herb has been popularly used for replenishing qi and blood, strengthening the spleen and harmonizing the stomach .Previous studies (in vitro and in vivo) proved: the n-butanol extraction of Potentilla anserina L. (NP) showed a remarkably protective effect on hypoxia cardiomyocytes. Protective effects of NP against pituitrin-induced acute myocardial ischemic injury were also observed.1 In this study, we investigated the effect of NP on hypoxia-induced cortical neuron of rat. Furthermore, we attempted to investigate the influence of NP on inflammatory mediators of oxygen deprivation-injured cortical neurons.

The effect of n-butanol extraction of Potentilla Anserina l. on hypoxia-induced inflammatory factors expression of wistar rat cortical neuron