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The glucose model for the study of diabetes complications is too general to be useful in finding cure for, or prevention of, diabetes complications. A model, based on blood plasma Vitamin B Deficiency in diabetes mellitus patients, explains why diabetes complications selectively affect some organs and resist traditional treatment. It predicts that the daily blood plasma vitamin B deficiency initiates a concatenation of events that culminate in organ dysfunction described as diabetes complications and that complications affecting all organs are curable and preventable with vitamin B supplementation. This was tested. Method: A continuous Open Trial was started in 2008 with one a day ingestible tablets given to type 2 diabetes mellitus patients with symptoms of diabetes complications affecting one or more organs. The tablet contained nicotinamide (15.0mg), thiamine hydrochloride (12.5mg) and calcium-d-pentothenate (11.0mg). Results: Cures of early-stage diabetes complications affecting the eye, kidney, and the skin were reported. Continued use of the therapy has prevented reappearance of symptoms of diabetes complications for over 6 years. No adverse effect has been reported. Conclusion: The cures, improvements and prevention of diabetes complications accomplished by the therapy predicted by the Blood Plasma Vitamin B Deficiency model makes the model a potent tool in the study of diabetes complications. Perspective: Future studies involving more patients, including insulin dependants, will be useful. Preventing diabetes complications with vitamin B supplementation as prophylactic represents a major breakthrough, in both human and economic terms, in the fight against the predicted type 2 diabetes mellitus epidemic.

journal of diabetes, metabolic disorders and control

Vitamin B Blood Plasma Deficiency Model for the Study of Diabetes Complications Demonstrates Potential for the Cure and Prevention of Complications in Type 2 Diabetes Mellitus Patients