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Pyrimidine nucleus has a wide spectrum use in medicinal chemistry. Based on structure activity relationship of pyrimidine nucleus we are going to synthesize 4-amino-2-methyl-6-phenylpyrimidine-5-carbonitrile derivatives. In this structure one primary amine group is free at 4th position. Schiff base has excellent antibacterial, antifungal, antiviral activities due to presence of azomethine (CH=N) group. Schiff base compounds have extensive applications in various fields such as analytical, inorganic, organic, and biological fields. They have excellent pharmacology application prospects in the modern era and are widely used in the pharmaceutical industry. In the present work in silico docking studies of five Schiff base compounds were carried out against Staphylococcus aureus.

In-silico approach: docking study of novel Schiff base congeners of pyrimidine nucleus