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Effect of trimebutine on the gastroduodenal motility was studied in conscious fasted dog with chronic implantation of electrodes and force transducers. During motor quiescence, trimebutine at 1.0-2.0 mg/kg i.v. produced action potentials and contractions similar to those developed during phase III (the period of intense action potential and contractile activity), which has been known to be physiologically important. Metoclopramide (1.0-2.0 mg/kg i.v.) induced contractile activity different from that during phase III, and hyoscine-N-butylbromide (0.1 mg/kg i.v.) produced no action potentials and contractions.

Contractions of the stomach and duodenum induced by trimebutine in conscious fasted dogs.