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In guinea pigs, rabbits and dogs the movements of the intramurl portion of the common bile duct were studied. The results obtained were summarized as follows.1. The histological examinations revealed that the intramural bile duct was surrounded with muscles which were derived from the external muscle layers of the duodenum.2. The contraction waves which were rhythmically originated in the most proximal part of the duodenum, propagated then to the intramural bile duct to give rise to contractions of it; as a result the bile contained in it was expelled into the duodenal cavity.3. In guinea pigs Auerbach's plexus of the duodenom was continued to that of the intramural bile duct without any interruption.4. From the results described above it may be presumed that the expelling of the bile proceeds as follows: In the full vigor of digestion which continues for 1 to 3 hours after a meal, every time when the stomach peristalsis arrives at the pylorus a small amount of the content is expelled into the duodenum. The content thus expelled stimulates on the one hand the hormonal mechanism concerned with the production of secretin and on the other hand the mucosal intrinsic reflex into action. The former causes an increase of the bile secretion, while the latter an increase of duodenal contraction waves which in turn triggers contractions of the intramural bile duct, both mechanisms thus accelerating the expelling of the bile. When the digestion turns to the declining stage, the bile secretion decreases and contraction waves grow weak; as a result the expelling of the bile decreases. The corollary is that the gall bladder is not regarded as an indispensable organ, although on the one hand it takes a role of the reservoir when the bile secretion is increased to an undue extent and on the other hand it produces an elastic recoil which promotoes the filling of the bile into the intramural bile duct.

THE MECHANISM OF THE EXPELLING OF THE BILE INTO THE DUODENAL CAVITY