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Ex situ analyses of human myometrial tissue has been used to investigate the regulation of uterine quiescence and transition to a contractile phenotype. Following concerns about the validity of cultured primary cells, we examined whether myometrial tissue undergoes culture-induced changes ex situ that may affect the validity of in vitro models.

journal of smooth muscle research

The expression of genes involved in myometrial contractility changes during &lt;i&gt;ex situ&lt;/i&gt; culture of pregnant human uterine smooth muscle tissue