English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The pharmacokinetics of fluoxetine were evaluated in two phylogenetically distant dog breeds. The quantification method was fine-tuned and validated through the mean, standard deviation and coefficient of variation (CV) for each sampling point. The CV values were around 2%. The detection limit was 3.36 ng/ml and corresponded to three times the signal noise of the blank sample. The limit of quantification (LOQ) was 10.53 ng/ ml. The chromatographic analysis indicated that the maximum concentrations of fluoxetine were reached at two hours post-administration (Akika Inu: 41.8 ± 0.6 ng/ml; German Shepherd: 45.3 ± 1.4.0 ng/ml), while the minimum concentrations were reached at 80 hours (Akika Inu: 3.9 ± 0.1 ng/ml; German Shepherd: 3.9 ± 0.1 ng/ml). A significant difference between breeds was only found in the values reached at 2 h post-administration (p<0.05). Results may indicate that due to the differences in the time curve, drug management might be different between phylogenetically different breeds.

Determinación del curso temporal de fluoxetina y norfluoxetina en perros Pastor Alemán y Akita Inu