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The Piper aduncum, also known as “Matico” in Peru, is a plant used as a healing, anti-diarrheal, anti-inflammatory, anti-cancer and other traditional uses plus1; These effects have been demonstrated as the antimicrobial2 and cytotoxic effect, the latter using bioguided fractionation, observing the effect on leaf extracts with dichloromethane on KB cells (nasopharyngeal carcinoma)3 and the essential oil on lung carcinoma, colon adenocarcinomas, adenocarcinoma of breast, amelanotic melanoma, cervical carcinoma, prostate carcinomas, chronic myeloid leukemia and normal mouse fibroblasts; in addition to oral toxicity in mice, finding null and toxic antitumor effect4. In the present study, the in vitro antiproliferative activity of the methanolic extract of Piper aduncum leaves on the AGS cell line (gastric adenocarcinoma) acquired from the ECACC (European Authenticated Cell Culture Collection) was evaluated, using a colorimetric technique with the resazurine indicator, evaluating the results within 24 and 48 hours of having exposed the extract to different factors: 1000, 500, 250, 125, Citar como: Miranda-García, V. y Bonilla, P. (2019). Actividad antiproliferativa del extracto metanólico de hojas de Piper aduncum sobre células de cáncer gástrico. Ciencia e Investigación 2019 22(2):29-34. Recibido: 21/08/2019 Aceptado: 07/11/2019 Correspondencia: Nombre: Victor Miranda Garcia Correo: victoremga@hotmail.com