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Part of the behavior in mammalian species is genetically programmed, and gene targeting technology using embryonic stem cells provides a powerful tool for the molecular analysis of genes involved in such behavior. Here we present how behavioral alterations were produced by disruption of an endogenous Fyn tyrosine kinase. These results may indicate that mutant mice produced by the gene targeting are useful for molecular analyses in mammalian behaviors and supply of animal models for human diseases.

Behaviral Abnormalities of Gene Targetted Mice.