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Clinical and pathological changes were investigated on acute phase in two-kidney Goldblatt hypertensive rats. Systolic blood pressure, plasma renin activity, plasma aldosterone and juxtaglomerular cell count (JGCC) increased slightly as early as 7 days after operation. Systolic blood pressure and plasma renin activity rose in the course of time after operation. Juxtaglomerular index (JGI) and JGCC of the clipped kidneys increased and JGI of the opposite kidneys decreased with the increase in systolic blood pressure. These results suggested that juxtaglomerular cells had an important role on acute phase in two-kidney Goldblatt hypertensive rats.

Clinical and Pathological Findings on Acute Phase in Two-kidney Goldblatt Hypertensive Rats