English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Matrix metalloproteinases (MMPs) play an important role in cartilage degradation in rheumatoid arthritis (RA). The inhibition of MMP-3 mRNA expression, in particular, is an interesting therapeutic target in RA. The green tea polyphenol, epigallocatechin-3-gallate (EGCG), is known to inhibit MMP mRNA expression. However, the action of the black tea polyphenol, theaflavin-3,3'-digallate (TF3), on MMP mRNA expression in chondrocytes is not well understood. The ability for the polyphenols TF3 and EGCG to affect the mRNA expression of MMPs, members of the a disintegrin and metalloproteinase protein family (ADAMs), tissue inhibitors of metalloproteinases (TIMPs) or the 67 kDa laminin receptor (67LR) was tested in interleukin-1 ƒÀ-stimulated mouse chondrocytes in vitro. Mouse chondrocytes were obtained from neonatal ddy mice. After 1 week, TF3 or EGCG was added to the cultured mouse chondrocytes with or without IL-1 ƒÀ . TF3 suppressed interleukin-1 ƒÀ-induced increases in MMP-3, MMP-9 and MMP-13 mRNA expression to an equal or greater degree than EGCG, while ADAM-15 and 67LR mRNA expression did not change significantly. TF3 recovered interleukin-1 ƒÀ-induced suppression of TIMP-3 mRNA expression. However, ADAM-17 mRNA production was induced by TF3. This study suggests that TF3 may have a stronger effect than EGCG in controlling the degradation of cartilage in the inflamed joint, and has the therapeutic potential to prevent cartilage destruction via inhibition of MMPs.

Effect of Theaflavin-3, 3'-digallate on Matrix Metalloproteinases in Mouse Chondrocytes