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It is not fully known if there are signi cant differences in the incidence of post-operative nausea and vomiting(PONV)in patients undergoing laparoscopic surgery under general anesthesia following administration of des urane compared to other conventional maintenance anesthetics, such as sevoflurane and propofol. This study was aimed to address this issue using network meta-analysis of relevant randomized controlled trials. Summary effect sizes were calculated as odds ratios (ORs)with 95% con dence intervals(CIs). The incidence of PONV after administration of different anesthetics was compared by surface under the cumulative ranking curve(SUCRA)analysis. The odds of des urane vs sevo urane, des urane vs propofol, and sevo urane vs propofol contributing to the incidence of PONV were 0.44(95% CI, 0.12-1.61), 2.43(95% CI, 0.72-8.26), and 5.50(95% CI, 1.7816.93), respectively. The SUCRA scores for des urane, sevo urane, and propofol were 48.3, 5.6, and 96.1, respectively. The incidence of PONV after desflurane administration did not differ signi cantly from that after sevo urane and propofol administration. However, the odds of PONV occurring after sevo urane administration were signi cantly higher than those after propofol administration. Moreover, the SUCRA score after desflurane administration was greater than that after sevo urane administration. These results con rm the safety of des urane regarding PONV in patients undergoing laparoscopic surgery under general anesthesia.

showa university journal of medical sciences

The Effects of Desflurane Versus Conventional Maintenance Anesthetics on the Incidence of Post-Operative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery