English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Our group previously demonstrated the suppressive effect of glucagon-like peptide-1(GLP-1)on macrophage-driven atherosclerosis in apolipoprotein E-de- cient (apoE ­/­ )mice. In the present study we investigated the suppressive effect of GLP-1 on the atherogenic phenotype of vascular smooth muscle cells(VSMCs) in vivo using apoE ­/­ mice, and the proliferation and migration of human VSMCs in vitro. A 4-week infusion of GLP-1 in 17-week-old apoE ­/­ mice significantly reduced the proliferative VSMC phenotype stained with SMemb. Platelet-derived growth factor(PDGF) -BB signicantly stimulated the proliferation of human aortic VSMCs by three fold. Both 0.1 and 1 nmol / l GLP-1 signicantly suppressed the PDGF-induced VSMC proliferation, and this suppressive effect was significantly abolished by the GLP-1 receptor antagonist exendin(9−39)(50 nmol / l) . The GLP-1 receptor agonists liraglutide(100 nmol / l)and exendin-4(100 nmol / l)mim- icked GLP-1, signicantly suppressing PDGF-induced VSMC proliferation. PDGF- BB signicantly stimulated the migration of human aortic VSMCs by 1.7 -fold, and this effect was signicantly suppressed by 1 nmol / l GLP-1. Thesendings suggest that GLP-1-related treatments may prevent the progression of atherosclerotic lesions by suppressing the proliferation and migration of VSMCs, which are characteristic features of atherosclerosis.

showa university journal of medical sciences

Glucagon-like Peptide-1 Suppresses the Proliferation and Migration of Vascular Smooth Muscle Cells: Implications for Preventive Effects on Atherosclerosis