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This study compared results from Gd-EOB-DTPA on two different phases of 3T MRI with those from Tc-99m-GSA hepatic scintigraphy and hepatic function tests. Twenty-four patients with liver tumor were included in this study. All patients underwent Gd-EOB-DTPA-enhanced-MRI and Tc-99m-GSA hepatic scintigraphy. Clearance index (HH15) and receptor index (LHL15) were calculated for the Tc-99m-GSA, while signal intensities (SI) of liver at pre-injection and at 4 / 20 min post-injection, and of spleen at 4 min / 20 min were measured (SIpre, SI4min, SI20min, SIsp4min, SIsp20min, respectively) for the Gd-EOB-DTPA-MRI. Liver activity at 15 min by Tc99m-GSA scintigraphy or biochemical liver function values were compared with liver spleen contrast at 4 min (LSC4min=SI4min / SIsp4min) or 20 min postinjection (LSC20min=SI4min / SISP20min), and the increase in ratio at 4 min (IR4min=SI4min / SIsp4min) or 20 min (IR20min=SI20min / SIpre). Total bilirubin levels (T-bil), serum albumin levels (Alb), prothrombin activity, and the indocyanine green clearance test (ICG) results were also analyzed. There were statistically significant correlations in all comparisons between GdEOB-DTPA and Tc-99m-GSA. The highest coefficient of correlation was obtained in IR4min (LHL15 : r=0.795, P<0.001 ; HH15 : r=-0.782, P<0.001), with IR20min (LHL15 : r=0.690, P<0.01 ; HH15 : r=-0.528, P<0.05), LSC4min (LHL15 : r=0.458, P<0.05 ; HH15 : r=-0.626, P<0.05), and LSC20min (LHL15 : r=0.443, P<0.05, HH15 : r=-0.609, P<0.05) also signi cantly correlated. Correlations in hepatic function data were observed between IR4min and T-bil / Alb, and IR20min and Alb. In 3T-MRI using GdEOB-DTPA, the SI of liver at preto post-injection (especially at 4 min) signi cantly correlated with the corresponding Tc-99m-DTPA scintigraphy results, and with some biochemical liver function data.

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A Study of Correlation between Gd-EOB-DTPA-enhanced MRI Using the 3T MRI System and Tc-99m-GSA Hepatic Scintigraphy/Hepatic Function Tests in Prehepatectomy Cases