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The aim of this retrospective study was to evaluate L-type amino acid transporter 1(LAT1)expression in colorectal cancer with invasion to the subserosal layer(T3) , its relationship with clinicopathological characteristics, and its potential metastatic signicance. LAT1 expression was measured by i mmunohistochemistry in tumors from 65 patients with primary colorectal carcinomas. LAT1 expression was deemed positive when more than 10% of the tumor cells showed distinct membranous immunoreactivity. Positive LAT1 expression was demonstrated in 29.2%(19 of 65)of primary tumors. LAT1 expression showed no signicant relationship with clinicopathological character- istics, such as age, gender, tumor location, tumor size, macroscopic/microscopic classication, or lymph node metastasis. However, LAT1 expression showed a positive relationship with liver metastasis(P<0.05) . LAT1 expression in cancer cells may be a good marker for predicting potential metastasis to the liver in colorectal cancer.

Positive Relationship between L-type Amino Acid Transporter 1 Expression and Liver Metastasis in T3 Colorectal Cancer