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In our department, we provide treatment for malignant head and neck tumors with the goal of preserving organs and function. We report the treatment outcomes for ve patients with maxillary cancer who underwent S-1 and nedaplatin treatment with concurrent radiation therapy (SN therapy)in our department from April 2005 to March 2009. The patients included one case classi ed as T2N0M0 and four cases classi ed as T4N0M0. All patients were male and were aged between 29 and 67 years with a mean age of 55.6 years. Among the ve cases, four achieved cancer-free survival with preservation of all functions after undergoing treatment. In the remaining case, the tumor did not disappear but was locally controlled via superselective arterial injection and CyberKnife treatment ; however, pulmonary metastasis occurred and the patient is surviving with cancer. SN therapy has allowed a reduction in the extent of surgery required and the preservation of organs and function. It will be necessary to study an increased number of cases in the future to determine the survival rate and the effectiveness of organ and function preservation in maxillary cancer patients after SN therapy.

The Effectiveness of Simultaneous Combination Therapy Using S-1 and Nedaplatin with Radiation for Five Cases of Maxillary Cancer