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Short-term (3-7 days), high doses of creatine (20g/d) and/or sodium bicarbonate (0.5g/kg body weight) supplementation increase exercise performance during short term high intensity activities; however, it remains unclear whether long-term, low doses of these supplements have a positive impact on exercise performance. The purpose of this study was to determine the effects of long-term (8 weeks), low dose creatine supplementation on exercise performance, and whether combining creatine and sodium bicarbonate supplementation has an additive effect. Sixty-three healthy, habitually active, adults (28 M, 35 W; 22+2 years; 23+ 3 BMI) were randomly assigned by sex to one of three supplement groups: placebo (PL), creatine only (3g/day; Cr), or creatine plus sodium bicarbonate (3g creatine plus 1g sodium bicarbonate; Cr+Sb) for 8 weeks. Before and after supplementation subjects completed two exercise performance tests on separate days. Subjects completed repeated Wingate sprint tests (6 x 10 second sprints) and changes in the slope across the 6 sprints (rate of decline) was analyzed between groups. We also collected 5 km time-trial and the data were analyzed using repeated measures ANOVA. In the repeated sprint test, peak power output slope was significantly decreased (P=0.04) in PL (-83%) and Cr+Sb (-82%) but did not change in Cr alone and was significantly better (P=0.03) than Pl and Cr+Sb. Similarly, mean power output slope significantly decreased (P<0.001) in PL (-73%) and Cr+Sb (-150%), but not in Cr alone. In the 5 k time-trial, PL (-0.4%) and Cr+Sb (+0.5%) had no significant change (P>0.05) v in time to completion. However, Cr alone significantly improved time to completion (-3%; P=0.01). Taken together, these data suggest that long-term, low dose creatine supplementation increases exercise performance but adding sodium bicarbonate supplementation has no beneficial impact on exercise performance. vi ACKNOWLEDGMENTS I would like to express my deepest appreciation to my committee chair and mentor, Dr. Todd Hagobian, for his excellent guidance, patience, and knowledge. I am extremely grateful for all the time and energy that he invested and for the research skills that he taught me. The skills that I have learned from Dr. Hagobian are invaluable and will undoubtedly help me throughout my career. Without his supervision and assistance, this thesis would not have been possible. I would also like to thank my thesis committee members, Dr. Suzanne Phelan and Jennifer Olmstead. They were always willing to take time out of their busy schedules to assist me with any questions I …

THE EFFECTS OF 8 WEEKS OF LOW DOSE SUPPLEMENTATION OF CREATINE AND SODIUM BICARBONATE ON EXERCISE PERFORMANCE