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A leptospirose e uma zoonose que acomete animais domesticos, silvestres e o homem, afeta multiplos orgaos e causa grave disfuncao renal e hepatica . O objetivo deste estudo foi avaliar os perfis bioquimicos hepatico e renal de Cerdocyon thous (Cachorro do mato) de vida livre sororreagentes a sorovariedades de Leptospira spp. Foram colhidas amostras de sangue de 16 individuos de vida livre, de diferentes regioes no Brasil, das quais as amostras soropositivas foram destinadas a realizacao das analises bioquimicas de aspartato amino-transferase (AST), alanino amino-transferase (ALT), gama-glutamil transferase (GGT), ureia (UV), creatinina e albumina. Considerando os parâmetros propostos por Santos (1999), os valores medios de ALT (59,32 U/L) e AST (79,03 U/L) apresentaram-se elevados. O aumento de ALT no soro indica lesao hepatica de natureza inflamatoria, toxica ou degenerativa, sendo que os niveis de sua elevacao estao na dependencia do grau e duracao da lesao, obtendo-se concentracoes maiores nos casos agudos (SANTOS, 1999) . As concentracoes sericas medias de albumina encontraram-se diminuidas (1,82 g/dL). Niveis de albumina podem apresentar-se reduzidos pela producao diminuida, em casos de insuficiencia hepatica cronica ou por perda aumentada quando ha glomerulonefrite (SANTOS, 1999). Um animal apresentou alteracao na concentracao serica de ureia (138 mg/dL) e outro em GGT (122,4 U/L). De acordo com Wohl (1996), o aumento das enzimas hepaticas, da ureia e creatinina, podem ser devidos aos disturbios hepatico e renal. Sao necessarios mais estudos sobre esta doenca nos animais selvagens, contribuindo assim com projetos de conservacao, manejo, prevencao e controle desta zoonose. Ademais, observou-se na literatura que os dados de parâmetros bioquimicos sericos sao escassos ou ausentes para especies selvagens. SUMMARY Leptospirosis is a zoonosis that affects wild and domestic animals, as well as humans. It affects multiple organs and cause severe renal and hepatic dysfunction. This study aims to evaluate the liver and kidney biochemical profiles of Cerdocyon thous (crab-eating fox), free-living and seroreacting to the serovars of Leptospira spp. We collected blood samples from 16 free-living animals from different regions in Brazil, of which the seropositive samples were referred to the biochemical analysis of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl (GGT), urea (UV), creatinine and albumin. According to the parameters proposed by Santos (1999), the mean values ​​of ALT (59.32 U/L) and AST (79.03 U/L) can be considered high. The increase of ALT in the serum indicates hepatic injury of inflammatory, degenerative or toxic nature. The ALT levels are increased depending on the degree and duration of the injury, with higher concentrations found in acute cases (SANTOS, 1999). The average serum concentrations of albumin were lower (1.82 g/dL). Albumin levels may be present at reduced levels as a result of decreased production, which happens in cases of chronic liver failure or increased loss when glomerulonephritis is present (SANTOS, 1999). One animal had altered serum urea (138 mg/dL) and another in GGT (122.4 U/L). According to Wohl (1996), increased liver enzymes, urea and creatinine may be due to liver and kidney disorders. Further studies are needed on this disease in wildlife, contributing to conservation projects, as well as, management, prevention and control of this zoonosis. Moreover, in the literature there is a lack or very few available data about the serum biochemical parameters for wildlife.

ars veterinária

AVALIAÇÃO DOS PERFIS BIOQUÍMICOS HEPÁTICO E RENAL EM CERDOCYON THOUS (CACHORRO DO MATO) SORORREAGENTES A LEPTOSPIRA SPP. NO TERRITÓRIO BRASILEIRO / EVALUATION OF LIVER AND KIDNEY BIOCHEMICAL PROFILES OF Cerdocyon thous (CRAB EATING FOX) SEROPOSITIVE TO...