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Nas ultimas decadas, tem-se observado a emergencia de microrganismos resistentes aos antibioticos, dentre os quais se destaca o genero dos Staphylococcus spp. resistente a meticilina (MRS). Essas linhagens nao sao comumente relatadas em animais, entretanto, nos ultimos anos, ha registros de aumento de casos de infeccoes em animais domesticos (RICH et al., 2005; MIDDLETON et al., 2005). O presente trabalho teve como objetivo identificar isolados de MRS e verificar o indice de resistencia multipla a antimicrobianos (MAR). As amostras foram obtidas de casos clinicos atendidos no Hospital Veterinario da Universidade Estadual de Maringa, onde foram utilizadas 48 amostras de Staphylococcus spp triadas por disco-difusao com oxacilina e cefoxitina. O perfil de resistencia a antibioticos foi realizado segundo as normas recomendadas pelo CLSI veterinario (2008) para disco-difusao com 27 antimicrobianos. O indice MAR e determinado pelo numero de antibioticos resistentes pelo total testado, considerando-se valores iguais ou superiores a 0,2 como indicativos de resistencia multipla (KRUMPERMAN, 1983). Das 48 amostras, 29 (60,4%) apresentaram resistencia a oxacilina, sendo que 26 dessas amostras tambem apresentaram resistencia a cefoxitina, o que indica amostras positivas para MRS e mostrando indices mais elevados do que encontrados por Coelho et al, 2007, 33,8%. Das 29 amostras resistentes a oxacilina, 27 (93,1) apresentaram indice MAR maior ou igual a 0,2 (entre 0,26 e 0,8), uma vez que isolados resistentes a oxacilina tendem a apresentar resistencia a outras classes de antibioticos. Ja as 19 amostras sensiveis aos discos de cefoxitina e oxacilina, apenas 3 (15,8%) obtiveram indice MAR maior ou igual a 0,2 (entre 0,32 a 0,56). O uso incorreto, associado a selecao natural dos microrganismos, provavelmente, resultou no fenomeno da resistencia, tanto na medicina veterinaria quanto na humana, o que mostra a importância do controle aos agentes antimicrobianos uma vez encontrados altos indices de resistencia pelos microrganismos. SUMMARY The recent decades have seen the emergence of antibiotic resistant microorganisms, among which stands out the methicillin-resistant Staphylococcus spp. (MRS). These strains are not commonly reported in animals; however, in recent years, there are reports of increasing cases of infections in domestic animals (RICH et al., 2005; MIDDLETON et al., 2005). This study aimed to identify MRS isolates and check the index of multiple antimicrobial resistance (MAR). The samples were obtained from clinical cases seen at the Veterinary Hospital of the Universidade Estadual de Maringa, where 48 strains of Staphylococcus spp. were screened by disk diffusion with oxacillin and cefoxitin. The profile of antibiotic resistance was performed according to the standards recommended by the veterinarian CLSI (2008) for disk diffusion with 27 antimicrobials. The MAR index is determined by the ratio of the number of antibiotic resistant by the total tested, considering values ​​equal to or greater than 0.2 as indicative of multiple resistance (KRUMPERMAN, 1983). Of the 48 samples, 29 (60.4%) were resistant to oxacillin while 26 were also resistant to cefoxitin, which indicates MRS positive samples. These rates were higher than the 33.8% reported by Coelho et al., 2007. Of the 29 oxacillin-resistant samples, 27 (93.1%) had MAR index greater than or equal to 0.2 (between 0.26 and 0.8) since  oxacillin- resistant strains tend to be resistant to other classes of antibiotics. On the other hand, of the 19 samples sensitive to oxacillin and cefoxitin disks, only 3 (15.8 %) displayed MAR index greater than or equal to 0.2 (from 0.32 to 0.56). Misuse of antibiotics associated with the natural selection of organisms probably resulted in the resistance phenomenon, both in human and in veterinary medicine, which shows the importance of controlling antimicrobial agents once high rates of resistance by the microorganisms are determined.

ars veterinária

RESISTÊNCIA MULTIPLA A ANTIMICROBIANOS EM STAPHYLOCOCCUS SPP. E DETECÇÃO DE AMOSTRAS METICILINA RESISTENTES / MULTIPLE ANTIMICROBIAL RESISTANCE IN Staphylococcus spp. AND DETECTION OF METHICILLIN RESISTANT ISOLATES