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Objective: to study the plasma content of B_type natriuretic peptides in coronary heart disease patients prepared for surgery under extracorporeal circulation and to assess the association of the level of these biomarkers with the data of clinical and functional studies. Material and methods. The levels of active B_type natriuretic peptide were determined by immunofluoresence assay in the blood of 52 patients aged 57.8±1 years. The patients' baseline clinical condition was in New York Heart Association (NYHA) Functional Class I—IV. The left ventricular ejection fraction was 59.6±1.2%. The plasma concentration of the inactive N_terminal fragment of the BNP prohormone (NT_proBNP) was estimated by elec_ tric chemiluminescence technique in 61 patients aged 54.6±1.18 years. The patients' clinical condition was in NYHA Functional Class II—IV. The left ventricular ejection fraction was 51.5±1.6%. Results. The plasma content of B_type natri_ uretic peptide in the examinees was 48.5±5.9 pg/ml. The level of the biomarker correlated with the NYHA functional class (r=0.4; p=0.005), the electrocardiographic signs of postinfarct cardiosclerosis (r=0.29; p=0.04), and left ventricular ejec_

The Preoperative Level of B-Type Natriuretic Peptides and the Results of Clinical and Functional Studies of Cardiosurgical Patients