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1) 20 (22.2%) infants who had received the exogenous surfactant Curosurf in the combined therapy of HMD; 2) 19 (21.1%) babies with HMD who had taken Surfactant BL; 3) 25 (27.8%) surfactantuntreated infants who had died from HMD; 4) 26 (28.9%) very preterm neonates with extremely low birth weight who had died within the first hour of life. The lungs were histologically and morphometrically examined. Results. The study demonstrated the specific course of HMD when exoge nous surfactants and artificial ventilation were used. The contributors to the development of the disease are intranatal amniotic fluid aspiration and intranatal fetal hypoxia. Conclusions. Artificial ventilation and the use of exogenous surfac tants do not block the generation of hyaline membranes. The latter differ in formation time, form, and location. The differ ences in a cell response to hyaline membranes were found in the neonatal infants receiving exogenous surfactants. The char acteristic morphological signs of the disease for all the neonates enrolled in the study are alveolar and bronchial epithelial

Pulmonary Changes in Preterm Neonates with Hyaline Membrane Disease (a Clinicomorphological Study)