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Effects of electrical stimulation of the mesencephalic pressor area (central gray stratum and adjacent portions) on renin release were studied in the chloralosed dogs.Renin release was measured by simultaneous collection of arterial and venous blood samples taken by the catheter introduced into renal vein under fluoroscopy.Mesencephalic stimulation provoked marked increase in renin release. Dorsal portion of mesencephalic pressor area is more effective than ventral portion in inducing renin release.

Increased Renin Release Evoked by Mesencephalic Stimulation in the Dog