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Effective renal plasma flow was determined by using I-131 labeled iodo-ortho-hippurate in 17 Chinese patients admitted to the coronary care unit with uncomplicated acute myocardial infarction. The first determination, immediately after admission, was significantly higher than the second determination done a week later, 444.5 +/- 153.9 vs. 371.1 +/- 124.9 ml/min (p &lt; 0.02). The initial rise of effective renal plasma flow (ERPF) after acute myocardial infarction seemed to be correlated to the initial elevation of atrial natriuretic peptide (ANP), which was determined sequentially 6 times in each patient (91.3 +/- 39.4, 25.6 +/- 9.7, 37.4 +/- 12.3, 51.8 +/- 18.2, 65.6 +/- 20.8, 57.4 +/- 19.2 pg/ml, respectively). It was concluded that, in the presence of uncomplicated acute myocardial infarction, patients may show renal vasodilatation, and that the elevation of ANP may play some role in this.

Effective Renal Plasma Flow Response and Atrial Natriuretic Peptide in Patients with Uncomplicated Acute Myocardial Infarction.