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We measured the coronary blood flow and concentrations of prostaglandin E1(PGE1), PGF2 alpha, and lactate from the ischemic myocardium of dogs treated with either SG-75 or indomethacin. There was a significant increase of coronary blood outflow from the ischemic myocardium after ligation in dogs given SG-75 and in control dogs compared with indomethacin-treated dogs. The release of lactate from the ischemic myocardium decreased significantly in dogs with SG-75 compared with the indomethacin and control group. The concentration of PGE1 rose significantly after ligation in dogs with SG-75 compared indomethacin-treated and those in control dogs. A significant release of PGE1 from the ischemic area of the myocardium treated with SG-75 was clearly demonstrated at 60 min after ligation of the LAD coronary artery. Also, a significant release of PGF2 alpha from the ischemic area of the myocardium was demonstrated at 15 min after ligation. There was a significant correlation between the increase of coronary outflow and PGE1 release from the ischemic myocardium ( 4= 0.70, p less than 0.01). However, no significant correlation was demonstrated between the increase of coronary outflow and PGF2 alpha. These results show a close relation ship between increased coronary outflow induced by SG-75 and increased release of PGE1. Thus, a beneficial effect of SG-75 on the ischemic myocardium was demonstrated.

SG-75 induction of increased coronary outflow and PGE1 from ischemic areas in dogs with experimental myocardial infarction.