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In an attempt to elucidate the mechanism of the systemic hypotension produced by the rapid intravenous injection of 20percent saline, experiments were made using the intracoronary injection technique and transeptal left atrial puncture in a total of 25 dogs. Accompanying apnea and bradycardia were considered to be due to the pulmonary reflex via the vagus. Scrutiny of systemic hypotension produced after injection of hypertonic saline into varying cardiovascular chambers showed that the injection into the left side of the heart also resulted in the same degree of hypotension as that of the right side, and that pressure fall was separated into early and late dips, about which the genesis was discussed and the former was attributed to the coronary effect. Electrocardiographic analysis revealed that the ST and T changes were the proof of the arrival of saline at the coronary circuit and their mechanisms were mentioned. From these results the authors emphasized the possible role of coronary effect by the agent and suggested the transient myocardial failure in the production of systemic hypotension.

Circulatory and Respiratory Effects of Hypertonic Saline with Special Reference to the Coronary Effect