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The elevated levels of plasma renin activity (PRA) in stroke-prone SHR rats (SHRSP) at several months of age were reported by Matsunaga et al (Jap Circulat J 39: 1305, 1975) and Morita and Okamoto (Jap Heart J 18: 573, 1977). Matsunaga et al (Jap Circulat J 40: 889, 1976) divided SHRSP into 2 groups on the basis of water turnover: one had significantly higher water intake and urine volume than the other. In the present study, blood pressure (BP), PRA, water, and electrolytes excretion were determined in SHRSP and compared with those in stroke-resistant SHR rats (SHRSR) and Wistar-Kyoto rats (WKY).

Plasma Renin Activity and Excretion of Water and Electrolytes in Stroke-prone SHR Rats