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espanolCon el fin de evaluar las principales propiedades antioxidantes y antibioticas del exocarpio del fruto de Santol (Sandoricum koetjape), se realizo una bioprospeccion sobre este, asi como una caracterizacion del contenido de polifenoles totales y proantocianidinas. Para lo anterior, al material seco y molido del exocarpio se le realizaron diferentes pruebas cuantitativas y fraccionamientos cromatograficos con diversas resinas, con el proposito de obtener metabolitos puros o mezclas de ellos mas concentrados. Las fracciones y extractos fueron analizados empleando el metodo de Folin-Ciocalteu (polifenoles totales), DMAC (proantocianidinas totales) y DPPH (actividad antioxidante), utilizando siempre un patron tradicional y uno propio de la muestra. Los resultados obtenidos con este ultimo fueron hasta un 80 % mas alto en comparacion con los patrones tradicionales; ademas, se determino como las fracciones con un mayor contenido de proantocianidinas presentan una mayor actividad antibiotica, con un 73 ± 4 % sobre la bateria S. Aureus y un 42 ± 2 % sobre Bacilus spp., ambos analisis realizados por el metodo de Kirby-Bauer. EnglishA bioprospection was conducted of santol fruit exocarp (Sandoricum koetjape), in order to evaluate its main antioxidant and antibiotic properties. In addition, total polyphenols and proanthocyanidins present were characterized. In order to obtain pure metabolites or more concentrated blends, dry and ground exocarp was subjected to different quantitative tests and chromatographic fractions with various resins. Fractions and extracts were analyzed using the Folin-Ciocalteu (total polyphenols), DMAC (total proanthocyanidins) and DPPH (antioxidant activity) method, using a traditional pattern and one from the sample. Results obtained with the latter were up to 80% higher compared to traditional patterns. It was also determined that fractions with a higher proanthocyanidin content have a higher antibiotic activity, that is 73 ± 4% on the S. Aureus battery and 42 ± 2% on Bacilus spp., both analyzed using the Kirby-Bauer method.

Estudio bioprospectivo, actividad antibiótica y antioxidante del exocarpio del fruto de santol (Sandoricum koetjape)