English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Both decreased insulin sensitivity, and impaired insulin secretion are 2 major pathophyisologies for type 2 diabetes (T2DM). There are two phases of ISEC-the first (1st ISEC) and second phase (2nd ISEC). In this study, we tried to build an equation to predict 2nd ISEC. Totally, 82 subjects, including 15 with normal fasting glucose, 26 with pre-diabetes and 41 with T2DM were enrolled. They received a modified low dose graded glucose infusion (M-LDGGI). The M-LDGGI is a simplified version of Polonsky’s method. The results were interpreted as the slope of the changes of plasma insulin against the glucose levels. The slopes of these curves were regarded as the 2nd ISEC. If only metabolic syndrome (MetS) components were analyzed, the equation was built as the following: log (2nd ISEC) = -2.400- 0.088 • (fasting plasma glucose, FPG + 0.072 • (body mass index, BMI). After fasting plasma insulin (FPI) was added , the equation was shown as the following: log (2nd ISEC) = -2.316- 0.093˙FPG + 0.049 • BMI+ 0.434 • log(FPI). The second equation provided a greater accuracy to determine 2nd ISEC than first one in the external validation group (r2 = 0.545 vs r2 = 0.423). Using MetS components, 2nd ISEC could be predicted with good accuracy. After adding FPI into the equation, the predictive power further increases. These equations could be widely used in daily practice and clinical settings.

Measuring Second Phase of Insulin Secretion by Components of Metabolic Syndrome