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In the Saccharomyces cerevisiae strains used for genome sequencing and functional analysis, the mitochondrial DNA replicase Mip1p contains a single nucleotide polymorphism changing the strictly conserved threonine 661 to alanine. This substitution is responsible for the increased rate of mitochondrial DNA point mutations and deletions in these strains.

genetics

A Single Nucleotide Polymorphism in the DNA Polymerase Gamma Gene of <i>Saccharomyces cerevisiae</i> Laboratory Strains Is Responsible for Increased Mitochondrial DNA Mutability

A Single Nucleotide Polymorphism in the DNA Polymerase Gamma Gene of Saccharomyces cerevisiae Laboratory Strains Is Responsible for Increased Mitochondrial DNA Mutability