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Insulin-like growth factors (IGF ́s) play a crucial role in controlling cancer cell proliferation, differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancer-related outcomes and survival, although its effects on IGF ́s are not well understood. This meta-analysis aimed to determine the effects of exercise in modulating IGF ́s system in breast cancer survivors. Methods: Databases of PuMed, EMBASE, Cochrane Central Register of Controlled Trials, EMBASE, ClinicalTrials.gov, SPORTdiscus, LILACS and Scopus were systematically searched up to November 2014. Effect estimates were calculated through a random-effects model of metaanalysis according to the DerSimonian and Laird method. Heterogeneity was evaluated with the I test. Risk of bias and methodological quality were evaluated using the PEDro score.

Inflammatory biomarkers and tumoral growth factors are modulated by exercise in breast cancer survivors