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PLCzeta(ζ) initiates Ca 2+  oscillations and egg activation at fertilization in mammals, but studies in mouse eggs fertilized by PLCζ knockout (KO) sperm imply that there is another slow acting factor causing Ca 2+  release. Here, I propose a hypothesis for how this second sperm factor might cause Ca 2+  oscillations in mouse eggs.

The soluble sperm factor that activates the egg: PLCzeta and beyond