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Missed abortion (MA) is a common disease in obstetrics and gynecology. More and more studies have focused on the relationship between miRNAs and pregnancy maintenance and its related diseases. The aim of this article is to explore the relationship between miRNA and MA. The expression of  miR-98  were detected by  in situ  hybridization and real-time PCR. Cell proliferation, activity and migration were measured via Edu, MTT, and transwell assays. The target genes of  miR-98  are identified by dual-luciferase activity assay. And the expression levels of target genes were determined by Western blot, real-time PCR and immunohistochemistry.  miR-98  was significantly up-regulated in placental villi from over 35 years old MA patients compared with the age-matched normal pregnant women. Up-regulation of  miR-98  suppressed the proliferation, activity and migration of the human trophoblast HTR-8/SVneo cell  in vitro .  miR-98  could bind to  GDF6  and  FAPP2  mRNA 3’-UTR and negatively regulate their expression. The downregulation of  miR-98  promoted cell proliferation, then knockdown of  GDF6  or  FAPP2  inhibited  miR-98 -mediated cell proliferation.  GDF6  and  FAPP2  expression in the placental villi from MA patients were decreased compared to normal placental tissues. The expression of  miR-98  in MA had an opposite relationship with the expression of  GDF6  and  FAPP2 . Overexpression of  miR-98  is associated with the occurrence of MA.  miR-98  prevents proliferation, viability and migration of trophoblast cells partially through targeting  GDF6  and  FAPP2 .

miR-98 is involved in missed abortion by targeting GDF6 and FAPP2