English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Spermatogonial stem cells (SSCs) and progenitor spermatogonia encompass the undifferentiated spermatogonial pool in mammalian testes. In rodents, this population is comprised of A single , A paired and chains of 4-16 A aligned spermatogonia. Although traditional models propose that the entire A single pool represents SSCs, and formation of an A paired syncytium symbolizes irreversible entry to a progenitor state destined for differentiation; recent models have emerged that suggest that the A single pool is heterogeneous, and A paired /A aligned can fragment to produce new SSCs. In this review, we explore evidence from the literature for these differing models representing SSC dynamics, including the traditional 'A single ' and more recently formed 'fragmentation' models. Further, based on findings using a fluorescent reporter transgene ( eGfp ) that reflects expression of the SSC-specific transcription factor 'inhibitor of DNA binding 4' ( Id4 ), we propose a revised version of the traditional model in which SSCs are a subset of the A single population; the ID4-eGFP bright cells (SSC ultimate ). From the SSC ultimate pool, other A single and A paired cohorts arise that are ID4-eGFP dim. Although the SSC ultimate possess a transcriptome profile that reflects a self-renewing state, the transcriptome of the ID4-eGFP dim population resembles that of cells in transition (SSCtransitory) to a progenitor state. Accordingly, at the next mitotic division, these SSC transitory are likely to join the progenitor pool and have lost stem cell capacity. This model supports the concept of a linear relationship between spermatogonial chain length and propensity for differentiation, while leaving open the possibility that the SSC transitory (some A single and potentially some A paired spermatogonia), may contribute to the self-renewing pool rather than transition to a progenitor state in response to perturbations of steady-state conditions.

A revised Asingle model to explain stem cell dynamics in the mouse male germline