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Systemic intravenous infusion of physiological concentrations of PGF-2 alpha and its major metabolite, 13, 14-dihydro-15-keto-PGF-2 alpha (PGFM) into non-pregnant ewes possessing a corpus luteum induced the release of oxytocin-neurophysin. These results suggest that, during luteolysis, endogenous release of uterine PGF-2 alpha would be able to stimulate the release of ovarian oxytocin and oxytocin-neurophysin from the ovary.

reproduction

Effect of systemic intravenous infusion of PGF-2 and 13,14-dihydro-15-keto-PGF-2 on the release of oxytocin-associated neurophysin from the ovary in the ewe