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The effects of PGI-salt and PGI-2 methyl ester on intrauterine pressure (IUP) and uterine electromyographic activity (EMG) were examined in vivo in non-pregnant ovariectomized sheep. PGI-2 salt and PGI-2 methyl ester (50--200 micrograms) reduced significantly the frequency and amplitude of IUP cycles and also inhibited the associated uterine EMG activity. Injections of oxytocin (50 mU) or PGF-2 alpha (2 micrograms) partly overcame the inhibiton of IUP induced by the PGI-2 methyl ester. These results suggest that endogenous PGI-2 may be involved in the regulation of uterine activity in sheep.

Inhibition by PGI-2 of myometrial activity in vivo in non-pregnant ovariectomized sheep