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Administration of 100 micrograms LH-RH to cyclic ewes gave peak values of circulating LH similar to those found at the time of oestrus although the duration of elevated LH levels was less. There was also considerable individual variation in response. Pretreatment or simultaneous administration with melatonin (500 micrograms or 2 mg) did not alter the individual response to LH-RH.

Lack of effect of melatonin on the pituitary response to LH-RH in the ewe