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An IUD inserted into one uterine horn caused an increase in its weight when this was compared with that of the contralateral control horn in rats. Such an increase could be partly prevented by treating the animals with indomethacin and aspirin. It is suggested that the IUD-induced increase in weight is at least in part mediated by release of prostaglandins.

INHIBITION BY ASPIRIN AND INDOMETHACIN OF UTERINE HYPERTROPHY INDUCED BY AN IUD