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Stricker & Gruether (1928, 1929) were the first to observe that whole pituitary extracts could initiate lactation in pseudopregnant ovariectomized rabbits. Greatly assisted by the many advantages of the specific pigeon crop sac response for isolation and quantitative assay of the effective protein, Riddle, Bates & Dykshorn (1933) isolated it and named it 'prolactin'. Since this early work, prolactin has been shown to have an important luteotrophic r\l=o^\lein many species. In this r\l=o^\leit is usually associated with LH. In studying the part played by prolactin in reproductive processes, we have investigated its secretion throughout the oestrous cycle and during pregnancy in the sheep, and have studied the effects of replacement therapy in hypophysectomized and pituitary stalk-sectioned ewes.

POSSIBLE ROLE OF PROLACTIN DURING THE OESTROUS CYCLE AND GESTATION IN THE EWE